3rd Chromosomal Instability as a Driver of Human Disease Conference
3rd Chromosomal Instability as a Driver of Human Disease Conference is organized by Fusion Conferences Ltd and will be held from Oct 04 - 07, 2021 at Dolce CampoReal Lisboa, Lisbon, Portugal. Target Audience: This meeting will appeal to Molecular...
3rd Chromosomal Instability as a Driver of Human Disease Conference is organized by Fusion Conferences Ltd and will be held from Oct 04 - 07, 2021 at Dolce CampoReal Lisboa, Lisbon, Portugal. Target Audience: This meeting will appeal to Molecular/Cell Biologists/Geneticists & Biochemists interested in genome stability. Researchers interested in the molecular basis of cancer, neurodegenerative diseases and ageing and those with an interest in high throughput genetic and pharmacological screening methods will also find the conference highly relevant along with those wishing to exploit genome maintenance abnormalities in tumour cells for therapeutic benefit. Synopsis: This conference is a continuation of the DNA Replication as a Source of DNA Damage series. The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities. Key Sessions: • Pathways for repair of DNA damage and disrupted DNA replication forks • Screening tools for analysis of genome maintenance pathways and for development of new therapeutics • Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins • Chromosome instability as a driver of tumorigenesis, neurodegeneration and ageing • Exploitation of defects in chromosome maintenance in cancer treatment Educational Need: Chromosome instability is involved in several human diseases and is a feature of natural ageing. This conference will bridge fundamental studies on the mechanisms by which cells maintain genome stability with applications of these studies aimed at the development of new therapies. Hence, the conference will bridge basic biology and clinical applications in this rapidly advancing field. Attendees should be able to obtain a full picture of the current status of the field, as well as to interact with prominent research leaders driving the clinical application of the latest research.